Other first XI matches in 2021
| 25 Mar 2021 | Other matches in England 2021 | Derbyshire v Yorkshire | The Incora County Ground, Derby | Drawn |
| 25 Mar 2021 | Other matches in England 2021 | Leicestershire v Derbyshire | Uptonsteel County Ground, Leicester | Drawn |
| 29 Mar 2021 | Other matches in England 2021 | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | Lost by 6 wkts |
| 03 Apr 2021 | Other matches in England 2021 | Derbyshire v Cardiff University Centre of Cricketing Excellence | The Incora County Ground, Derby | Drawn |
| 27 Jun 2021 | India in England 2021 | Derbyshire v India A | The Incora County Ground, Derby | Abandoned |
| 20 Jul 2021 | Royal London Cup 2021 | Derbyshire v Shropshire | The Incora County Ground, Derby | Cancelled |
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