Other second XI matches in 2021
| 06 May 2021 | Other matches in England 2021 | Derbyshire Second XI v Warwickshire Second XI | The Incora County Ground, Derby | Lost by 3 wkts |
| 17 May 2021 | Other matches in England 2021 | Worcestershire Second XI v Derbyshire Second XI | Cherry Hill Road, Barnt Green | Abandoned |
| 27 May 2021 | Other matches in England 2021 | Derbyshire Second XI v Lancashire Second XI | Christchurch Meadows, Belper | Won by 6 wkts |
| 27 May 2021 | Other matches in England 2021 | Derbyshire Second XI v Lancashire Second XI | Christchurch Meadows, Belper | Won by 5 runs |
| 13 Jul 2021 | Other matches in England 2021 | Derbyshire Second XI v Nottinghamshire Second XI | The Copper Yard, Denby Village | Cancelled |
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