Largest Margin of Runs Defeat
| 191 runs | by Somerset | The Cooper Associates County Ground, Taunton | 2022 | tt11106 |
| 101 runs | by Hampshire | The 3aaa County Ground, Derby | 2017 | tt6448 |
| 99 runs | by Yorkshire | Emerald Headingley Cricket Stadium, Leeds | 2020 | tt8908 |
| 94 runs | by Nottinghamshire | Trent Bridge, Nottingham | 2022 | tt11019 |
| 86 runs | by Leicestershire | County Ground, Derby | 2006 | tt379 |
| 79 runs | by Leicestershire | County Ground, Derby | 2013 | tt3750 |
| 67 runs | by Lancashire | Emirates Old Trafford, Manchester | 2015 | tt4955 |
| 66 runs | by Lancashire | Old Trafford, Manchester | 2005 | tt201 |
| 60 runs | by Warwickshire | Edgbaston, Birmingham | 2015 | tt5016 |
| 59 runs | by Yorkshire | Queen's Park, Chesterfield | 2014 | tt4443 |
| 56 runs | by Lancashire | County Ground, Derby | 2009 | tt1323 |
| 55 runs | by Leicestershire | The Pattonair County Ground, Derby | 2019 | tt8056 |
| 55 runs | by Durham | Emirates Riverside, Chester-le-Street | 2020 | tt8966 |
| 53 runs | by Nottinghamshire | Trent Bridge, Nottingham | 2007 | tt665 |
| 50 runs | by Lancashire | County Ground, Derby | 2005 | tt220 |
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